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S-adenosylmethionine synthase isoform type-1
- Molecular classification
- Enzyme
01
Overview
S-adenosylmethionine synthase isoform type-1 (MAT1A) is an enzyme that catalyzes the formation of S-adenosylmethionine (SAM or SAMe) from methionine and ATP. SAM is a crucial methyl donor involved in numerous methylation reactions throughout the body and plays a central role in cellular metabolism. MAT1A is highly expressed in the liver and plays a key role in hepatic metabolism and liver health. Deficiency or dysfunction can contribute to liver diseases such as cirrhosis or hepatocellular carcinoma due to impaired methylation capacity. Therapeutically, exogenous SAMe has been used for its anti-inflammatory properties and potential benefits in chronic liver disease management.
- Other names
- MAT1AAMS1MATA1AdoMet synthase 1Methionine adenosyltransferase 1
02
Mechanism of action
SAMe acts as a methyl donor in various methylation reactions and participates in other metabolic pathways.
03
Biological functions
Methylation reactionsPolyamine synthesisTranssulfurationGlutathione production
04
Disease associations
Liver diseaseCirrhosisHepatocellular carcinomaMetabolic disorders
05
Safety considerations
Potential for adverse effects with exogenous SAMe supplementation.Altered methionine metabolism
06
Interacting drugs
S-adenosylmethionine (SAMe)
07
Biomarkers
MAT1A expression levels in liver tissueSAMe levels
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