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Target intelligence / Profile preview
Methionine Adenosyltransferase
- Molecular classification
- Enzyme
01
Overview
Methionine adenosyltransferase (MAT), also known as S-adenosylmethionine synthetase, is a key enzyme in cellular metabolism that catalyzes the synthesis of S-adenosylmethionine (SAM or AdoMet) from methionine and ATP. SAM is the principal biological methyl donor, essential for transmethylation reactions affecting DNA, proteins, lipids, and other small molecules. Dysregulation of MAT activity has been implicated in several diseases including liver disorders/injury and cancer progression/metastasis. Targeting specific MAT isoforms has become an area of interest for drug development against cancer, neurodegenerative diseases, depression, osteoarthritis, migraine, among others.
- Other names
- S-Adenosylmethionine synthetaseMAT
02
Mechanism of action
Inhibition of SAM synthesis by targeting MAT isoforms
03
Biological functions
CatalysisMethyl group donorRegulation of DNA methylationProtein modificationLipid metabolismPolyamine biosynthesisCell growth and differentiation
04
Disease associations
Liver disorders/injuryCancer progression/metastasisNeurodegenerative diseasesDepressionOsteoarthritisMigraine
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