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S-phase kinase-associated protein 1 pseudogene
- Molecular classification
- Other (Pseudogene)
01
Overview
S-phase kinase-associated protein 1 pseudogene (ENSG00000228154) is a non-coding sequence in the human genome with high similarity to the protein-coding SKP1 gene. SKP1 encodes a core component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which regulates protein degradation and cell cycle progression[4][6]. However, this pseudogene does not produce a functional protein and has lost the capacity for protein-coding function due to sequence disablement[2][5]. While some pseudogenes can have regulatory effects via RNA, there is no evidence that this particular locus has biological or clinical significance. Therefore, it is not a therapeutic target and does not fit conventional categories such as receptor, enzyme, transporter, or transcription factor[2][5].
- Other names
- SKP1P1EMC19OCP2TCEB1LTCEB1PTCEB1P1
02
Biological functions
Other (has no direct protein function; some pseudogenes can regulate parental gene expression via RNA mechanisms, but no such function is documented for this locus)
03
Disease associations
Other (No established direct disease association; pseudogenes in general may occasionally regulate parental gene expression, but no evidence for this specific locus)
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