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S-phase kinase-associated protein 2 (SKP2)
- Target
- SKP2
- Molecular classification
- F-box protein, E3 ubiquitin ligase component, SCF complex component
01
Overview
S-phase kinase-associated protein 2 (SKP2) is an F-box protein and a key component of the SCF E3 ubiquitin ligase complex. It plays a central role in cell cycle regulation, particularly in promoting the transition from G1 to S phase by targeting specific cell cycle inhibitors, such as p27^Kip1^, for degradation. SKP2 acts as an oncogene in multiple solid tumors and hematological malignancies, with overexpression associated with enhanced tumorigenic potential and poor prognosis. It is also involved in metabolic regulation and apoptosis. SKP2 is being explored as a therapeutic target, and small-molecule inhibitors are under investigation for anti-cancer therapy development.
- Other names
- p45FLRFFBL1
02
Mechanism of action
Small-molecule inhibitors against Skp2 or disruption of SCF-Skp2 interactions
03
Biological functions
Cell cycle regulationG1/S transitionUbiquitinationProtein degradationApoptosis regulationMetabolic regulation
04
Disease associations
CancerGlioblastoma multiformeProstate cancerBreast cancerHepatocellular carcinomaUrothelial bladder carcinoma
05
Safety considerations
Inhibition may affect cell cycle regulation in normal cellsPotential for off-target effects due to involvement in multiple pathways
06
Biomarkers
SKP2 overexpression (prognostic marker in gliomas/GBM)
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