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Target intelligence / Profile preview
S1 RNA-binding domain-containing protein 1 (SRBD1)
- Target
- SRBD1
- Molecular classification
- RNA-binding protein, Chromosome-associated protein, Structural constituent of ribosome (predicted), Other
01
Overview
S1 RNA-binding domain-containing protein 1 (SRBD1) is a highly conserved, essential protein that serves as a key component of the mitotic chromatid axis[1]. SRBD1 binds to DNA and is required for proper sister chromatid segregation during cell division, acting in prophase to safeguard the decatenation process and prevent missegregation of chromosomes[1]. It contains an S1 RNA-binding domain, a well-characterized motif also found in a variety of RNA-binding proteins, and may participate in mRNA translation or ribosome function, though its principal role appears related to genome stability in dividing cells[1][2][3][4]. Disease-association studies implicate SRBD1 in susceptibility to certain forms of glaucoma, but it is not currently a validated therapeutic target[4].
- Other names
- S1 RNA binding domain 1SRBD1FLJ10379H_NH0576F01.1WUGSC:H_NH0576F01.1S1 RNA-binding domain-containing protein 1
02
Mechanism of action
Not applicable (no drugs known to target SRBD1)
03
Biological functions
Chromosome individualization and segregation: Key component of the mitotic chromatid axis; essential for proper sister chromatid segregationPrevention of aberrant DNA structures during mitosis: Ensures proper decatenation (untangling) of sister chromatids, especially during prophaseRNA-binding: Binds single-stranded RNA (ssRNA) and may be involved in mRNA translationStructural constituent of the ribosome (predicted)Other (if additional functions are verified by new research)
04
Disease associations
SRBD1 has been associated through genetic studies with susceptibility to glaucoma (normal tension glaucoma and primary open angle glaucoma), but there is currently no evidence for a direct role as a therapeutic target in any disease
05
Safety considerations
None reported. SRBD1 is an essential gene required for cell division; thus, manipulating its expression could be expected to cause severe cellular defects or lethality
06
Interacting drugs
None known. No drugs are reported to directly interact with or target SRBD1
07
Biomarkers
None established
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