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Target intelligence / Profile preview
S100 Calcium Binding Protein A9 (None)
- Target
- None
- Molecular classification
- Calcium-binding protein, S100 protein, DAMP
01
Overview
S100A9, also known as MRP14 or calgranulin B, is a calcium-binding protein primarily expressed in myeloid cells. It forms heterodimers with S100A8 (calprotectin) and is involved in inflammation, immune response, and antimicrobial activity. It acts as a DAMP and regulates inflammatory processes via TLR4 signaling. Aberrant expression is linked to several diseases and represents a therapeutic target.
- Other names
- MRP14Calgranulin BCalprotectin L1H subunitBM-009Calgranulin-BDKFZp686B04128Leukocyte L1 complex heavy chainMacrophage Migration inhibitory factor-related protein 14Monocyte MRP-14/MRP15/MRP16Protein S100-A960B8AGCAGBCFAGCGLBL1AGLIAGMAC387MIFP14S100A9
02
Mechanism of action
Small molecule inhibitors targeting pro-inflammatory functions of extracellular S100A9 are under development
03
Biological functions
InflammationImmune responseAntimicrobial activityCell cycle regulationCell differentiationChemotaxisPhagocytosis
04
Disease associations
Chronic inflammatory diseasesCystic fibrosisJuvenile rheumatoid arthritisCrohn’s diseaseCancer
05
Safety considerations
Amplifies inflammation via TLR4/RAGE; modulation of immune responses without broad suppression is a therapeutic challenge.
06
Biomarkers
Inflammation biomarker
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