Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
S100 Calcium-Binding Protein B (S100B)
- Target
- S100B
- Molecular classification
- S100 EF-hand calcium-binding protein, DAMP (Damage-Associated Molecular Pattern)
01
Overview
S100 calcium-binding protein B (S100B) is a member of the S100 family of low molecular-weight, EF-hand calcium-binding proteins. It is primarily expressed in astrocytes within the central nervous system. The protein functions both intracellularly and extracellularly, playing roles in cellular regulation, signaling, and as a clinical biomarker. At elevated concentrations, extracellular S100B can act as a damage-associated molecular pattern molecule (DAMP). Regulation by melittin has been suggested for epilepsy treatment research purposes. Elevated serum or CSF levels are used clinically to indicate brain injury. It may also serve as an indicator for melanoma progression/metastasis.
02
Mechanism of action
Regulation by melittin has been suggested for epilepsy treatment research purposes.
03
Biological functions
Cell cycle regulationNeurite outgrowthNeurotrophic supportModulation of energy metabolismCalcium bindingSignal transductionRegulation of cell differentiation
04
Disease associations
Alzheimer’s diseaseDown syndromeEpilepsyAmyotrophic lateral sclerosisMelanomaSchwannomaType I diabetes mellitusNeuroinflammationNeurodegenerationBrain Injury
05
Safety considerations
Elevated extracellular S100B can act as a DAMP, contributing to inflammation or neurodegeneration depending on context
06
Interacting drugs
Melittin
07
Biomarkers
Elevated serum or CSF levels indicate brain injury/blood-brain barrier disruptionIndicator for melanoma progression/metastasis
Beyond the preview
Go deeper on S100 Calcium-Binding Protein B (S100B).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on S100 Calcium-Binding Protein B (S100B).