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S100P-p53 Interaction
- Molecular classification
- Protein-Protein Interaction
01
Overview
The S100P-p53 interaction refers to the direct binding between the calcium-binding protein S100P and the tumor suppressor protein p53. This interaction has functional consequences for cell proliferation, apoptosis, and cancer progression. Disrupting this interaction is a potential therapeutic strategy for reactivating wild-type p53 function in cancers where it is suppressed due to high levels of interacting partners like S100P.
02
Mechanism of action
Disrupts S100P-p53 complex formation by competing for binding sites on S100P.
03
Biological functions
Cell proliferationApoptosisCell cycle regulationTumor suppression
04
Disease associations
CancerBreast carcinomaProstate carcinoma
05
Safety considerations
Potential off-target effects of S100P inhibitorsReactivation of p53 may have unintended consequences
06
Interacting drugs
Pentamidine
07
Biomarkers
S100P expression levelsp53 expression levelsWild-type p53 activity
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