Saccharomyces boulardii CNCM I-745 (S. boulardii CNCM I-745)

Saccharomyces boulardii CNCM I-745 is a strain of non-pathogenic probiotic yeast classified within the Saccharomyces cerevisiae species, originally isolated from fruit peels. It is administered orally as a live probiotic and exhibits resistance to stomach acid and antibiotics, allowing it to reach the intestines intact. Its health benefits derive from its ability to inhibit pathogen colonization, bind and degrade bacterial toxins, stimulate the production of secretory IgA, modulate inflammatory responses, and restore healthy gut microbiota. Clinically, it is widely used to prevent or treat various forms of diarrhea, restore gut flora following antibiotics, and support intestinal health during gastrointestinal infections and imbalances. Its action is multifactorial—physical (blocking pathogen adhesion), biochemical (breaking down toxins, supporting nutrient absorption), and immunological (boosting sIgA, modulating inflammation). While generally safe, vigilance is required when treating immunocompromised patients due to the rare risk of fungemia.

Other names

Saccharomyces boulardiiS. boulardiiS. boulardii CNCM I745SB CNCM I-745

Acts as a probiotic: competes with pathogens, degrades toxins (e.g., *C. difficile* toxins), restores microbiota, strengthens intestinal barrier, stimulates immune function, produces anti-inflammatory and trophic factors for gut health