Sad1 and UNC84 domain containing 1 (SUN1)

Sad1 and UNC84 domain containing 1 (SUN1) is a structural protein localized to the inner nuclear membrane, where it is a core component of the LINC (Linker of Nucleoskeleton and Cytoskeleton) complex[1][2][3][7]. SUN1 physically connects the nuclear lamina to the cytoskeleton, mediating nuclear positioning, movement, and the transmission of mechanical forces across the nuclear envelope[1][2][3]. It is essential for interkinetic nuclear migration in neuronal progenitors, the maturation of focal adhesions, actin cytoskeleton organization, and telomere attachment during meiosis[1][2]. Mutations in SUN1 have been associated with Emery-Dreifuss muscular dystrophy and rare developmental disorders, including neurological and muscular symptoms[1][2][4][5]. SUN1 is not a typical direct therapeutic target such as a receptor or enzyme, but its dysfunction is linked to various tissue pathologies due to deficits in nuclear-cytoskeletal communication[2][1][7].

Other names

SUN domain-containing protein 1KIAA0810UNC84AFLJ12407Protein unc-84 homolog ASad1/unc-84 protein-like 1Sad1 unc-84 domain protein 1sad1/unc-84 protein-like 1unc-84 homolog A