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Target intelligence / Profile preview
Sal-like protein 4 (None)
- Target
- None
- Molecular classification
- Transcription factor, Spalt-like zinc finger transcription factor
01
Overview
Sal-like protein 4 (SALL4) is a zinc finger transcription factor essential for the maintenance and self-renewal of embryonic stem cells (ESCs) and hematopoietic stem cells. It regulates pluripotency by interacting with key factors like OCT4, NANOG, and SOX2, and modulates the expression of genes involved in development. SALL4 functions as an oncogene in various cancers, promoting cell proliferation, migration, and chemotherapeutic resistance. Mutations can cause developmental syndromes. It is considered an attractive target for anti-cancer therapies.
- Other names
- SALL4
02
Mechanism of action
Molecular glues or targeted protein degraders aimed at modulating/degrading SALL4 activity directly within cancer cells
03
Biological functions
Stem cell maintenanceStem cell self-renewalRegulation of pluripotencyRegulation of development
04
Disease associations
CancerDevelopmental disorders
05
Safety considerations
Drug design against nuclear transcription factors lacking well-defined active sitesOff-target effects due to role in development
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