Target intelligence / Profile preview

Salicyl-AMP ligase

Molecular classification: Enzyme, ANL superfamily of adenylating enzymes

Overview

Salicyl-AMP ligase, also known as MbtA, is an enzyme that plays a critical role in the biosynthesis of mycobactin, a siderophore essential for iron acquisition in Mycobacterium tuberculosis. This enzyme catalyzes the first committed step in mycobactin biosynthesis, activating salicylic acid and transferring it to the aryl carrier protein MbtB. MbtA is considered an attractive target for novel antitubercular agents due to its essentiality in iron acquisition pathways unique to bacteria.

Other names: MbtASalicyl-S-ArCP synthetaseMycobactin biosynthesis protein MbtASalicyl-AMP ligase / salicyl-S-ArCP synthetase

Mechanism of action

Inhibition of salicyl-AMP ligase disrupts mycobactin biosynthesis, leading to iron starvation and reduced bacterial growth and virulence.

Biological functions

AdenylationThioesterificationMycobactin biosynthesisIron acquisition

Disease associations

InfectionTuberculosis

Safety considerations

Potential for off-target effects if inhibitors are not specific to bacterial enzymes.Development of resistance may occur if inhibitors are used improperly.

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