Salivary proteins and acquired pellicle components (AEP)

The salivary proteins and acquired pellicle components (AEP) constitute a complex biological interface formed by the selective adsorption of salivary constituents onto oral surfaces (Siqueira et al., 2012; Vacca Smith & Bowen, 2000). This acellular film, primarily composed of mucins, proline-rich proteins, statherin, and histatins, serves as a critical protective barrier against dental erosion by neutralizing acids and regulating calcium phosphate homeostasis (Hannig & Hannig, 2009). Beyond its protective role, the pellicle acts as a scaffold for the initial attachment of oral bacteria, thereby governing the formation and composition of dental biofilms (Lendenmann et al., 2000). Therapeutic agents such as fluoride and chlorhexidine interact with this layer to enhance remineralization or provide sustained antimicrobial activity, a property known as substantivity (Marsh et al., 2011). Understanding the proteomic profile of the pellicle is essential for developing targeted therapies for dental caries, periodontal disease, and xerostomia (Vitorino et al., 2006). Consequently, the pellicle is a primary target for oral health interventions aimed at maintaining the integrity of the tooth enamel and controlling pathogenic microbial colonization.

Other names

Acquired enamel pellicleSalivary pellicleDental pellicleEnamel pellicleSalivary proteome

Promotion of enamel remineralization, inhibition of pathogenic bacterial attachment, and provision of a protective diffusion barrier against dietary acids (Hannig & Hannig, 2009; Marsh et al., 2011).