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Salmonella enterica serotype Typhi antigen
- Molecular classification
- Polysaccharide, Lipopolysaccharide, Protein
01
Overview
Salmonella enterica serotype Typhi antigen refers primarily to the surface antigens present on the bacterium Salmonella enterica serovar Typhi, which causes typhoid fever. The most clinically significant of these is the Vi (virulence) capsular polysaccharide antigen, but other important antigens include O (somatic) and H (flagellar) antigens. The Vi capsule acts as a major virulence factor by reducing inflammatory responses, inhibiting phagocytosis, and increasing resistance to oxidative killing. Detection of antibodies against these antigens is used for diagnosis, and purified Vi polysaccharide has been developed into an effective vaccine.
- Other names
- Vi Capsular AntigenO AntigenH AntigenS. Typhi antigen
02
Mechanism of action
Antibody production against S. Typhi antigens
03
Biological functions
Immune evasionVirulenceMotilityImmune recognition
04
Disease associations
Typhoid feverInfection
05
Safety considerations
Potential impacts on vaccine efficacy due to natural variations/modifications in O-antigenLoss or absence of SPI-7 or viaB locus may result in increased invasiveness under certain conditions
06
Interacting drugs
Vi polysaccharide vaccine
07
Biomarkers
Antibodies against Vi antigenAntibodies against O antigenAntibodies against H antigen
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