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Target intelligence / Profile preview
Salmonella enterica serovar Typhi (S. Typhi)
- Target
- S. Typhi
- Molecular classification
- Bacterium, Gram-negative bacteria, Enterobacteriaceae
01
Overview
Salmonella enterica serovar Typhi is a Gram-negative bacterium that causes typhoid fever in humans. It is strictly adapted to human hosts and spreads through the ingestion of contaminated food or water. Key virulence factors include the Vi antigen and typhoid toxin. Effective prevention includes ensuring access to clean drinking water, proper hand hygiene, and safe food handling practices. Antibiotic therapy cures most cases if administered promptly; however, antibiotic resistance is an emerging concern.
- Other names
- Typhoid bacillusSalmonella Typhi
02
Mechanism of action
Antibiotics inhibit bacterial cell wall synthesis, DNA replication, or protein synthesis.
03
Biological functions
InfectionPathogenesisColonizationImmune evasion
04
Disease associations
Typhoid feverBacteremiaInfection
05
Safety considerations
Antibiotic resistanceCarrier state (asymptomatic infection)Relapse of infection
06
Interacting drugs
Antibiotics (e.g., fluoroquinolones, cephalosporins, azithromycin)
07
Biomarkers
Blood culture (presence of S. Typhi)Widal test (detects antibodies against O and H antigens)TyphiDOT (detects IgM and IgG antibodies)
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