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Target intelligence / Profile preview
Salmonella enterica serovar Typhi Antigens (S. Typhi Antigens)
- Target
- S. Typhi Antigens
- Molecular classification
- Polysaccharide, Lipopolysaccharide, Protein, Capsular Polysaccharide, Surface Antigen
01
Overview
Salmonella enterica serovar Typhi antigens are key molecular structures on the surface of the bacterium Salmonella Typhi, which causes typhoid fever. These include the O-antigen (somatic antigen), H-antigen (flagellar antigen), and Vi antigen (capsular polysaccharide antigen). These antigens play crucial roles in immune recognition, pathogenesis, diagnosis, and vaccine development by enabling the bacterium to evade host immunity and establish infection. Detection of antibodies against these antigens is used in diagnostic tests, and the Vi antigen is used in effective parenteral vaccines. Structural diversity and phase-variable modifications affect diagnostic accuracy and vaccine efficacy.
- Other names
- Typhoid fever antigensSalmonella Typhi surface antigensO-antigenH-antigenVi antigenSomatic AntigenFlagellar AntigenCapsular Polysaccharide Antigen
02
Mechanism of action
Vaccine-induced antibody production; diagnostic antigen detection
03
Biological functions
Immune recognitionHost-pathogen interactionAdhesionMotilityImmune evasionAntiphagocytosisAntiopsonic activitySerotyping
04
Disease associations
Typhoid feverInfectionBacterial pathogenesis
05
Safety considerations
Cross-reactivity between Salmonella serovarsPhase-variable modifications affecting vaccine efficacyVi-negative strains with altered virulence
06
Interacting drugs
Typhoid vaccines (Vi antigen)
2 more in the full profile.
07
Biomarkers
O-antigen antibodiesH-antigen antibodiesVi antigen antibodies
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