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Target intelligence / Profile preview
Salmonella enterica serovar Typhi Capsule (Vi antigen)
- Target
- Vi antigen
- Molecular classification
- Polysaccharide, Capsular Polysaccharide, Virulence Factor
01
Overview
The capsule of *Salmonella enterica* serovar Typhi, also known as the Vi antigen, is a surface-exposed extracellular polysaccharide that is a critical virulence factor. It enables immune evasion by inhibiting complement activation and neutrophil phagocytosis, and modulates inflammation, facilitating systemic spread during typhoid fever. The Vi capsular polysaccharide is the basis for current typhoid vaccines.
- Other names
- Vi capsular polysaccharideVi antigenSalmonella Typhi CapsuleVirulence capsular polysaccharide
02
Mechanism of action
Vaccines induce functional antibody responses that confer protection against typhoid fever by targeting the Vi antigen and promoting opsonization and clearance of S. Typhi.
03
Biological functions
Immune evasionComplement inhibitionInhibition of neutrophil phagocytosisIntracellular survivalModulation of inflammationAdhesion
04
Disease associations
Typhoid feverInfectionBacterial pathogenesis
05
Safety considerations
Potential for immune evasion mutationsVaccine efficacy can varyO-acetylation variability can affect vaccine efficacy
06
Interacting drugs
Typhoid vaccines (Vi polysaccharide based)
07
Biomarkers
Anti-Vi antibodies (vaccine efficacy)Vi antigen detection (diagnosis)
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