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Target intelligence / Profile preview
Salmonella enterica serovar Typhi Vi Capsular Polysaccharide (Vi antigen)
- Target
- Vi antigen
- Molecular classification
- Polysaccharide, Capsular Polysaccharide
01
Overview
The Vi capsular polysaccharide (Vi antigen) is a surface-expressed polysaccharide capsule found in Salmonella enterica serovar Typhi (S. Typhi), the causative agent of typhoid fever in humans. This capsule is a key virulence factor, distinguishing S. Typhi from most other Salmonella serovars. Its primary function is to enhance bacterial survival during infection by evading host immune responses. Expression of the Vi antigen correlates with increased virulence, and it serves as an important diagnostic marker for identifying S. Typhi. The purified Vi capsular polysaccharide is used as an active component in licensed typhoid vaccines.
- Other names
- Vi capsular polysaccharideVi polysaccharideVi antigen
02
Mechanism of action
Target for typhoid vaccines; elicits antibody production to prevent Salmonella Typhi infection.
03
Biological functions
Immune evasionInhibition of complement activationReduction of neutrophil chemotaxisSerum resistanceAdhesion
04
Disease associations
Typhoid feverSalmonella infectionInfection
05
Safety considerations
Vaccine-related adverse reactions (rare)Limited efficacy in certain populations
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