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Target intelligence / Profile preview
Salmonella enterica serovar Typhi Vi Polysaccharide Antigen (Vi Antigen)
- Target
- Vi Antigen
- Molecular classification
- Polysaccharide, Capsular Polysaccharide, Antigen
01
Overview
The Vi polysaccharide antigen is a capsular polysaccharide found on the surface of *Salmonella enterica* serovar Typhi (S. Typhi), the causative agent of typhoid fever in humans. This antigen is a key virulence factor and distinguishes S. Typhi (and some related serovars like Paratyphi C) from most other *Salmonella* strains, which do not express this capsule. It is composed primarily of α-1,4-linked N-acetylgalactosaminuronic acid residues. The Vi capsule inhibits phagocytosis by immune cells, reduces opsonization, dampens inflammatory responses, and increases infectivity. Purified Vi polysaccharide is used in effective vaccines against typhoid fever, inducing protective anti-Vi antibodies.
- Other names
- Vi polysaccharideVi capsuleTyphoid Vi antigen
02
Mechanism of action
Induction of anti-Vi antibodies
03
Biological functions
Immune evasionAnti-phagocytosisAnti-opsonizationImmunomodulationComplement resistance
04
Disease associations
Typhoid feverInfectionBacterial infection
05
Interacting drugs
Vi-polysaccharide vaccine
1 more in the full profile.
06
Biomarkers
Anti-Vi antibodies (for vaccine efficacy)
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