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Target intelligence / Profile preview
Salmonella enterica serovar Typhimurium O-antigen polysaccharide (O4) (O4 antigen)
- Target
- O4 antigen
- Molecular classification
- Polysaccharide, Lipopolysaccharide (LPS) component, O-antigen
01
Overview
Salmonella enterica serovar Typhimurium O-antigen polysaccharide (O4) is a specific structural component of the outer membrane lipopolysaccharide (LPS) of Salmonella enterica serovar Typhimurium. It is a key determinant in bacterial serotyping, immune recognition, and vaccine development. It consists of a repeating tetrasaccharide unit with a Man-Rha-Gal backbone and a unique dideoxyhexose sugar, abequose, which defines the O4 specificity. Antibodies targeting this epitope are crucial for protective immunity against infection.
- Other names
- Salmonella group B O-antigenGroup B O-antigenO:4 antigenSalmonella Typhimurium O4 polysaccharide
02
Biological functions
Immune recognitionVirulence factorAdhesionSerotyping
03
Disease associations
InfectionGastroenteritis
04
Safety considerations
Antigenic variation may impact vaccine efficacyEmergence of variants with altered glycosylation patterns
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