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Target intelligence / Profile preview
Salmonella Typhi Vi Polysaccharide Antigen (Vi Antigen)
- Target
- Vi Antigen
- Molecular classification
- Polysaccharide, Capsular Polysaccharide, Antigen
01
Overview
The Vi polysaccharide antigen is a capsular polysaccharide produced by Salmonella enterica serovar Typhi (S. Typhi). It is a virulence factor that enables immune evasion and is a key component of typhoid fever vaccines. It is composed of repeating units of (1-4)-2-deoxy-2-N-acetyl galacturonic acid and is variably O-acetylated. Immunization with the Vi antigen induces a T-cell independent antibody response that confers protective immunity against typhoid fever.
- Other names
- Vi capsular polysaccharideVi polysaccharideVi antigen
02
Mechanism of action
Stimulates production of protective antibodies against Salmonella Typhi
03
Biological functions
Immune evasionReceptor binding (DC-SIGN)Anti-inflammatory activityProtective surface layerElicits antibody production
04
Disease associations
Typhoid feverInfection
05
Safety considerations
Residual formaldehydePhenol preservative
06
Interacting drugs
Typhim Vi (vaccine)
07
Biomarkers
Vi-specific antibody levels
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