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Target intelligence / Profile preview
Salt-Inducible Kinase (SIK)
- Target
- SIK
- Molecular classification
- Serine/threonine kinase, AMPK-related kinase, Enzyme
01
Overview
Salt-inducible kinases (SIKs) are a family of serine/threonine protein kinases that belong to the AMP-activated protein kinase (AMPK) superfamily. They regulate diverse physiological processes, including metabolism, immune responses, circadian rhythms, and more. There are three main isoforms in mammals: SIK1, SIK2, and SIK3. They act as central mediators translating extracellular signals into transcriptional responses by phosphorylating substrates like CREB-regulated transcription coactivators (CRTCs) and class IIa histone deacetylases (HDAC4/5/7/9). SIKs are implicated in various diseases, including inflammatory diseases and cancer, making them potential therapeutic targets.
- Other names
- SIK1SIK2SIK3
02
Mechanism of action
SIK inhibitor
03
Biological functions
Sodium homeostasisMetabolic regulationImmune responseCircadian rhythm regulationCell divisionBone formationSkin pigmentationTranscriptional regulation
04
Disease associations
Inflammatory diseasesCancerHypertensionAcute kidney injuryOsteoporosisSkin pigmentation disordersObesityInsulin resistance
05
Interacting drugs
GLPG3312
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