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Target intelligence / Profile preview
Salt-inducible kinase 1 (SIK1)
- Target
- SIK1
- Molecular classification
- Serine/threonine-protein kinase, AMPK-related kinase, Salt-inducible kinase
01
Overview
Salt-inducible kinase 1 (SIK1) is a serine/threonine protein kinase and the founding member of the salt-inducible kinases, which are part of the AMP-activated protein kinase (AMPK) superfamily. SIK1 regulates multiple physiological processes, including transcriptional regulation, blood pressure homeostasis, and steroidogenesis. It is activated by LKB1-mediated phosphorylation and inhibited by PKA-mediated phosphorylation. Emerging evidence suggests that pan-SIK inhibition reduces pro-inflammatory cytokines, implicating therapeutic potential for inflammatory diseases.
- Other names
- MSKSNF1LKEIEE30
02
Mechanism of action
Pan-SIK inhibition reduces pro-inflammatory cytokines while increasing immunoregulatory cytokines
03
Biological functions
Transcriptional regulationBlood pressure homeostasisSteroidogenesisMEF2-dependent gene transcription modulationCREB-mediated gene expression influenceMyogenic differentiationImmune regulation
04
Disease associations
Cardiovascular diseaseInflammation
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