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Target intelligence / Profile preview
Serine/threonine-protein kinase SIK2 (SIK2)
- Target
- SIK2
- Molecular classification
- Enzyme, Protein kinase, Serine/threonine kinase, AMPK family
01
Overview
Serine/threonine-protein kinase SIK2 is a member of the AMP-activated protein kinase (AMPK) family and plays a pivotal role in regulating fatty acid oxidation, autophagy, immune response, glucose metabolism, and insulin signaling. It modulates the activity of transcription factors and is involved in T-cell development. SIK2 also plays a role in regulating glucose metabolism through control of the CRTC2-CREB function in white adipocytes and represses AKT/GSK3β/β-catenin signaling in gastric cancer. Due to its involvement in metabolic regulation and cancer-related pathways, SIK2 is a potential therapeutic target for metabolic disorders and certain cancers.
- Other names
- Salt-inducible kinase 2Qin-induced kinaseSNF1LK2QIK
02
Mechanism of action
Inhibition of SIK2 activity
03
Biological functions
Fatty acid oxidationAutophagyImmune responseGlucose metabolismInsulin signal transductionRegulation of transcription factor activityT-cell developmentRegulation of CREB-mediated transcription
04
Disease associations
Metabolic disordersDiabetesCancer
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