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Target intelligence / Profile preview
Serine/threonine-protein kinase SIK3 (SIK3)
- Target
- SIK3
- Molecular classification
- Enzyme, Protein Kinase, Serine/Threonine Kinase, AMPK family
01
Overview
Serine/threonine-protein kinase SIK3, also known as Salt-Inducible Kinase 3 (SIK3), is a member of the AMP-activated protein kinase (AMPK) family. It functions as a serine/threonine kinase and plays key roles in cellular energy regulation, metabolism, circadian rhythm, and response to environmental stressors. Dysregulation of SIK3 has been observed in certain diseases including cancer. Its role in metabolic pathways makes it a potential therapeutic target for metabolic disorders, circadian rhythm disturbances, neurobiology-related conditions like sleep disorders, and possibly cancer therapy development pipelines are ongoing targeting this molecule.
- Other names
- Salt-inducible kinase 3
02
Biological functions
ATP bindingMagnesium ion bindingProtein serine/threonine kinase activityRegulation of mTOR/TORC1 signalingRegulation of cell cycleRegulation of metabolismCircadian rhythm controlHomeostatic sleep/wake regulation
03
Disease associations
CancerMetabolic disordersCircadian rhythm disturbancesSleep disordersNeurobiology-related conditions
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