Salvador family WW domain-containing protein 1 (SAV1)

Salvador family WW domain-containing protein 1 (SAV1) is a ubiquitously expressed protein encoded by the SAV1 gene, characterized by two WW domains, a SARAH domain, and a coiled-coil region[1][5]. SAV1 functions as a key scaffold and adaptor within the Hippo signaling pathway, essential for organ size control and tumor suppression by restricting cell proliferation and promoting apoptosis through regulation of the kinase cascade involving MST1/2 and LATS1/2[1][6]. The protein binds to and stabilizes MST1/2, antagonizes STRIPAK complex–mediated suppression, and inhibits phosphatase activity targeting Hippo components, ultimately suppressing oncogenic YAP/TAZ-driven gene expression[2][4][6]. SAV1 also interacts with AKT, suppressing its activity and thus contributing further to its tumor suppressor functions[6]. Altered expression or activity of SAV1 is implicated in multiple cancers, including colorectal, liver, renal, lung, and pancreatic cancers, often correlating with disease progression and poor prognosis[3][6]. No drugs directly targeting SAV1 are currently known, but its role as a biomarker and central Hippo pathway component makes it a potential therapeutic target in oncology.

Other names

Protein salvador homolog 1WW45hWW45WWP4salvador45 kDa WW domain proteinWW domain-containing adaptor 45SAV1700040G09Riksalvador homolog 1