SANT and BTB domain regulator of class switch recombination (SANBR)

SANT and BTB domain regulator of class switch recombination (SANBR) is a protein-coding gene encoding a protein that contains both a SANT and a BTB domain[3][4]. SANBR acts as a negative regulator of class switch recombination (CSR), a critical process in B cells by which immunoglobulin production shifts from IgM/IgD to other antibody isotypes in response to antigenic stimulation[1][5]. Overexpression of SANBR in mouse splenic B cells inhibits CSR, and this negative regulatory activity depends on the BTB domain, which mediates homodimerization and interactions with corepressor proteins such as HDAC and SMRT[1][2]. SANBR belongs to the KIAA1841 family of BTB domain-containing proteins and is predicted to function primarily as a DNA-binding protein involved in gene regulation relevant to antibody diversification[1][4][6]. No known therapeutics, small molecules, or biomarkers targeting SANBR have been described, and there are no reported safety concerns or clinically relevant drug interactions for this gene.

Other names

KIAA1841SANT and BTB domain regulator of CSRSANBRSANT and BTB domain regulator of class switch recombination