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Saponins
- Molecular classification
- Glycosides, Immunomodulators, Adjuvants
01
Overview
Saponins are natural glycosides derived from plants that act as immunological adjuvants to enhance both innate and adaptive immune responses. TQL-1055 is a novel, semi-synthetic saponin-based adjuvant designed for vaccine applications, including tuberculosis (TB) vaccines. They interact with cell membranes and various pattern recognition receptors on antigen-presenting cells (APCs), stimulating these APCs to release inflammatory cytokines and chemokines, leading to recruitment of immune cells and enhanced immune responses.
- Other names
- TQL-1055
02
Mechanism of action
Saponins act as immunomodulators by interacting with cell membranes and pattern recognition receptors on antigen-presenting cells (APCs). They enhance antigen presentation, stimulate cytokine release, and promote both humoral and cellular immunity.
03
Biological functions
Innate immune activationAdaptive immunity enhancementAntigen presentationCytokine releaseB-cell activationT-cell activation
04
Disease associations
InfectionTuberculosisCancer (potential immunotherapy)
05
Safety considerations
ToxicityReactogenicityInflammation
06
Interacting drugs
ESAT‑6/Ag85B (antigens)
1 more in the full profile.
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