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Sarcoglycan Alpha Subunit (α-sarcoglycan)
- Target
- α-sarcoglycan
- Molecular classification
- Transmembrane protein, Sarcoglycan, Dystrophin-glycoprotein complex component
01
Overview
Alpha-sarcoglycan is a protein component of the sarcoglycan complex, which is part of the dystrophin-glycoprotein complex (DGC) in muscle cells. It plays a crucial role in maintaining muscle cell structure by stabilizing interactions between the cytoskeleton and the extracellular matrix. Mutations in the SGCA gene, encoding alpha-sarcoglycan, are associated with limb-girdle muscular dystrophy type 2D (LGMD2D).
- Other names
- Alpha-sarcoglycan50 kDa dystrophin-associated glycoprotein
02
Biological functions
Structural stabilization of muscle cellsLinking cytoskeleton to extracellular matrixMaintenance of plasma membrane integrity
03
Disease associations
Limb-girdle muscular dystrophy type 2D (LGMD2D)SarcoglycanopathyMuscular dystrophy
04
Biomarkers
Reduced alpha-sarcoglycan expression in muscle biopsies
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