Sarcolemmal membrane-associated protein (SLMAP)

Sarcolemmal membrane-associated protein (SLMAP) is a tail-anchored membrane protein found primarily in striated muscle and encoded by the SLMAP gene on human chromosome 3. SLMAP is involved in excitation-contraction coupling, myoblast fusion during development, and cell cycle regulation in cardiomyocytes[1][2][3][6]. It associates with the STRIPAK complex, regulates Hippo signaling, and is thought to impact cardiac electrophysiology by modulating calcium channel protein expression and trafficking[2][3][6]. Mutations in SLMAP are linked with Brugada syndrome, a life-threatening cardiac arrhythmia, and its altered expression is implicated in various diseases including cancer and diabetes[1][3][6]. Multiple isoforms exist, reflecting alternative splicing and tissue specificity. No currently approved therapeutic drugs are known to target SLMAP directly; its role as a target is investigational, mainly in cardiac arrhythmias and cancer contexts.

Other names

Sarcolemmal-associated proteinSLAPKIAA1601UNQ1847/PRO3577

Modulation of excitation-contraction coupling and calcium handling, regulation of sodium current by affecting channel trafficking