Sarcoma 180 (S180)

Sarcoma 180 (S180), or Crocker sarcoma, is an established transplantable murine tumor cell line frequently utilized in experimental oncology for the preliminary screening of potential anti-tumor agents. It is characterized by high malignancy, rapid growth, and the ability to be maintained in either solid or ascitic forms across various mouse strains. As a biological model rather than a specific molecular target (such as a receptor or enzyme), it serves as a readout for testing the efficacy of chemotherapeutics, natural products, and immunomodulators. Drugs interacting with this model typically exert their effects through direct cytotoxicity, induction of apoptosis, or by stimulating the host's immune system to recognize and eliminate the S180 cells. While historically significant for identifying compounds like lentinan, the S180 model is often criticized for its lack of direct translatability to human clinical oncology due to its mouse-specific origins and rapid growth kinetics.

Other names

S180 sarcomaCrocker sarcomaSarcoma 180 tumorS-180

Inhibition of tumor cell proliferation, induction of apoptosis, and modulation of the host immune response to suppress tumor growth in vivo.