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Target intelligence / Profile preview
Sarcoma antigen 1 (SAGE1)
- Target
- SAGE1
- Molecular classification
- Other (Cancer/testis antigen, tumor-specific antigen, not a classical enzyme, receptor, transporter, or transcription factor)
01
Overview
Sarcoma antigen 1 (SAGE1) is a cancer/testis antigen protein encoded by the SAGE1 gene, located on chromosome X. SAGE1 is highly expressed in various cancers including sarcomas, but is normally not expressed in adult tissues except for spermatogenic cells in the testis (and in some cases, placenta)[2][7][1]. Its restricted expression pattern and strong immunogenicity make it a promising target for cancer immunotherapy. Structurally, SAGE1 is classified as a cancer/testis antigen and has recently been identified as a master regulator of RNA polymerase II in cancer cells[3]. There are currently no known drugs directly targeting SAGE1, but its tumor-specific expression profile supports its evaluation as an immunotherapeutic target and potential diagnostic biomarker[2][3][7].
- Other names
- SAGECT14Cancer/testis antigen 14putative tumor antigen
02
Biological functions
Immune response (as a tumor antigen)Other (potential regulator of RNA polymerase II in cancer cells)
03
Disease associations
Cancer (specifically sarcoma, pan-cancer expression)Other (Spermatocytoma)
04
Safety considerations
Expression in normal testis but not other normal tissuesconsidered highly tumor-specific, but potential concern in targeting germ cells in immunotherapy
05
Biomarkers
Tumor antigen for cancer immunotherapy candidatecancer biomarker for tumors of various histological types, highly tumor-restricted expression
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