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Target intelligence / Profile preview
Sarcoplasmic reticulum Ca2+-ATPase (SERCA)
- Target
- SERCA
- Molecular classification
- Enzyme, P-type ATPase, Ion Transporter
01
Overview
Sarcoplasmic reticulum Ca2+-ATPase (SERCA) is a P-type ATPase enzyme located in the membrane of the sarcoplasmic reticulum (SR) within muscle cells. Its primary function is to transport calcium ions (Ca2+) from the cytosol into the SR lumen, utilizing energy derived from ATP hydrolysis. This process is essential for muscle relaxation following contraction by reducing cytosolic Ca2+ concentration. SERCA activity is crucial for excitation-contraction coupling in cardiac muscle and is regulated by proteins like phospholamban and sarcolipin. Dysfunction of SERCA, particularly SERCA2a, is implicated in heart failure.
02
Mechanism of action
Inhibition of calcium transport into the sarcoplasmic reticulum.
03
Biological functions
Calcium transportMuscle relaxationExcitation-contraction couplingNonshivering thermogenesis
04
Disease associations
Heart failure
05
Interacting drugs
Thapsigargin
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