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Target intelligence / Profile preview
Sarcoplasmic Reticulum Calcium Release Channel (RyR)
- Target
- RyR
- Molecular classification
- Ion channel, Calcium channel
01
Overview
The sarcoplasmic reticulum calcium release channel, primarily the ryanodine receptor (RyR), is a crucial ion channel in muscle cells responsible for releasing calcium ions from the sarcoplasmic reticulum (SR) into the cytoplasm. This calcium release initiates muscle contraction and is central to excitation-contraction coupling in skeletal, cardiac, and smooth muscle. There are three main isoforms: RyR1 (skeletal muscle), RyR2 (cardiac muscle), and RyR3 (less abundant, more broadly distributed). RyRs are large tetrameric complexes regulated by cytosolic calcium, accessory proteins, posttranslational modifications, and small molecules. Mutations in RyRs are linked to various diseases, including malignant hyperthermia and cardiac arrhythmias.
- Other names
- Ryanodine ReceptorRyR1RyR2RyR3
02
Mechanism of action
Modulation of calcium release from the sarcoplasmic reticulum
03
Biological functions
Calcium signalingMuscle contractionCardiac rhythm regulationExcitation-contraction coupling
04
Disease associations
Malignant hyperthermiaCentral core diseaseCatecholaminergic polymorphic ventricular tachycardiaMyopathiesArrhythmiasAtaxiasExocrine disorders
05
Safety considerations
Malignant hyperthermia susceptibilityArrhythmiasPotential for altered muscle contractility
06
Interacting drugs
Ryanodine
2 more in the full profile.
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