Sarcoplasmic reticulum calcium-transporting ATPase (SERCA)

The **Sarcoplasmic reticulum calcium-transporting ATPase (SERCA)** is an ATP-dependent membrane pump found in the sarcoplasmic reticulum (SR) of muscle cells and the endoplasmic reticulum (ER) of other cells. It maintains low cytosolic calcium levels by actively transporting calcium ions from the cytosol into the SR, which is essential for muscle relaxation after contraction and for a wide array of cellular processes dependent on intracellular calcium signaling. SERCA is regulated by small transmembrane peptides, such as phospholamban and sarcolipin, as well as recently described micropeptides. Dysregulation of SERCA activity is implicated in diseases including heart failure, muscular disorders, and neurodegenerative conditions, making it an important therapeutic target[1][3][5][8].

Other names

Sarcoendoplasmic reticulum calcium ATPaseSarcoplasmic/endoplasmic reticulum Ca^2+-ATPaseSR Ca^2+-ATPaseATP2A1 (gene)ATP2A2 (gene)Calcium ATPase

Inhibition or modulation of SERCA activity alters calcium uptake into the sarcoplasmic reticulum, thereby affecting cytosolic calcium levels, muscle contraction, and cellular signaling[3][8].