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Target intelligence / Profile preview
Sarcoplasmic Reticulum Calcium Uptake (SR Calcium Uptake)
- Target
- SR Calcium Uptake
- Molecular classification
- Transport Process, Calcium Transport, Cellular Physiology
01
Overview
Sarcoplasmic reticulum (SR) calcium uptake is the process by which calcium ions (Ca2+) are actively transported from the cytosol of muscle cells back into the sarcoplasmic reticulum. This process is essential for muscle relaxation following contraction and is a key regulator of intracellular calcium homeostasis. The primary driver is the SERCA pump, which uses ATP hydrolysis to translocate Ca2+ into the SR lumen. Calsequestrin buffers Ca2+ within the SR. Regulation involves proteins like phospholamban and sarcolipin, which modulate SERCA activity. Dysfunctional regulation at any step can have profound effects on overall cardiovascular health.
- Other names
- SR Ca2+ UptakeSarcoplasmic Reticulum Calcium ReuptakeSERCA-mediated Calcium Uptake
02
Mechanism of action
N/A
03
Biological functions
Muscle RelaxationCalcium HomeostasisRegulation of Muscle ContractionTermination of Muscle Contraction
04
Disease associations
CardiomyopathyHeart FailureDiastolic DysfunctionArrhythmiasMuscle disorders
05
Safety considerations
Dysregulation can lead to impaired muscle function and cardiovascular complications
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