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Target intelligence / Profile preview
SARS Coronavirus 2 Membrane Protein (M protein)
- Target
- M protein
- Molecular classification
- Viral Structural Protein, Integral membrane protein
01
Overview
The membrane (M) protein of SARS-CoV-2 is the most abundant structural protein in the coronavirus virion. It plays a central role in virus assembly, morphogenesis, and budding by organizing other structural proteins—spike (S), envelope (E), and nucleocapsid (N)—through direct physical interactions. The M protein is also a key target for host immune responses and has been considered as a potential target for vaccines and therapeutics.
- Other names
- CoV_MMembrane glycoprotein
02
Biological functions
Virus assemblyVirion morphogenesisScaffoldingMembrane curvature induction
03
Disease associations
InfectionCOVID-19
04
Safety considerations
Potential for off-target effects if targeting human homologuesResistance development
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