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SARS coronavirus 2 nucleocapsid protein
- Molecular classification
- Viral protein, RNA-binding protein
01
Overview
The nucleocapsid (N) protein is one of the four main structural proteins encoded by the SARS-CoV-2 genome. It is a highly conserved, multifunctional protein essential for viral replication and assembly. It binds to viral genomic RNA, compacting it into ribonucleoprotein complexes that fit inside virions and interacts with S, E, M proteins on the envelope to facilitate assembly of new virus particles. It is also involved in regulation of transcription and synthesis of viral RNAs during infection cycles. It is a major antigenic target for diagnostic tests and a promising drug target.
02
Mechanism of action
Disruption of RNA-binding or oligomerization (potential)
03
Biological functions
Genome packagingVirion assemblyRegulation of replicationRegulation of transcriptionRNA binding
04
Disease associations
Infection
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