Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
SARS coronavirus 2 ORF1ab polyprotein (None)
- Target
- None
- Molecular classification
- Viral polyprotein, Enzyme (precursor)
01
Overview
The ORF1ab polyprotein is a large, multifunctional protein encoded by the open reading frame 1ab (ORF1ab) gene of SARS coronavirus 2 (SARS-CoV-2). This gene occupies about two-thirds of the viral genome and is essential for viral replication and transcription. The polyprotein is produced through a unique mechanism involving ribosomal frameshifting, resulting in two main products: pp1a and pp1ab. These are subsequently cleaved into 16 nonstructural proteins (nsps), which form the core machinery for viral RNA synthesis, processing, and modification. Key components derived from this polyprotein—especially RdRp and Mpro—are major drug targets in COVID‑19 therapy development.
02
Mechanism of action
Various; examples: - Remdesivir: RdRp inhibitor - Paxlovid™/Nirmatrelvir: Mpro inhibitor - Molnupiravir: RdRp inhibitor
03
Biological functions
Viral genome replicationTranscription of subgenomic RNAsEvasion/modulation of host immune responsesViral RNA processing
04
Disease associations
Infection
05
Interacting drugs
Remdesivir
2 more in the full profile.
Beyond the preview
Go deeper on SARS coronavirus 2 ORF1ab polyprotein (None).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on SARS coronavirus 2 ORF1ab polyprotein (None).