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Target intelligence / Profile preview
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
- Target
- SARS-CoV-2
- Molecular classification
- Virus, RNA virus, Coronavirus
01
Overview
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel, zoonotic virus belonging to the family Coronaviridae. It is the causative agent of coronavirus disease 2019 (COVID-19), which led to a global pandemic. SARS-CoV-2 is closely related to bat coronaviruses and likely originated from such sources. The virus primarily infects cells expressing high levels of ACE2. Transmission occurs mainly via respiratory droplets or direct contact with contaminated surfaces. Symptoms range from mild upper respiratory illness to severe pneumonia and multi-organ failure.
- Other names
- COVID-19 virus2019-nCoVhCoV-19
02
Mechanism of action
Various, including inhibition of viral RNA polymerase, protease inhibition, and neutralization of the spike protein.
03
Biological functions
Viral replicationInfectionImmune evasionCell entryRNA transcriptionTranslation
04
Disease associations
COVID-19PneumoniaARDS (Acute Respiratory Distress Syndrome)Multi-organ failureMIS-C (Multisystem Inflammatory Syndrome in Children)MIS-A (Multisystem Inflammatory Syndrome in Adults)
05
Safety considerations
Rapid viral evolution and emergence of variantsPotential for drug resistanceVaccine-related adverse events (rare)Cytokine stormLong-term health consequences (Long COVID)
06
Interacting drugs
Remdesivir
5 more in the full profile.
07
Biomarkers
Viral load (PCR)Antibody titersInflammatory markers (e.g., IL-6, CRP, ferritin)Lymphocyte countOxygen saturation (SpO2)D-dimer
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