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Target intelligence / Profile preview
SARS-CoV-2 3C-like Protease (3CLpro)
- Target
- 3CLpro
- Molecular classification
- Enzyme, Protease, Cysteine protease
01
Overview
SARS-CoV-2 3C-like protease (3CLpro), also known as Mpro or main protease, is a cysteine protease essential for viral replication. It cleaves the two large polyproteins pp1a and pp1ab translated from the viral RNA genome at 11 conserved sites to release nonstructural proteins (nsps), which are crucial for viral transcription, replication, and recombination. The enzyme recognizes a specific cleavage sequence: Leu-Gln↓(Ser/Ala/Gly). Due to its essential role and the lack of close human homologs, it is a prime drug target for antiviral development.
- Other names
- MproMain proteasensp5
02
Mechanism of action
Inhibition of 3CLpro blocks processing of polyproteins into functional nsps, halting viral replication.
03
Biological functions
Viral replicationPolyprotein processing
04
Disease associations
Infection
05
Safety considerations
Potential for off-target effects, though low due to lack of homologous human proteases.
06
Interacting drugs
Z-FK-FMK
1 more in the full profile.
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