Target intelligence / Profile preview

SARS-CoV-2 3C-like proteinase (3CLpro)

Target: 3CLpro
Molecular classification: Enzyme, Cysteine protease

Overview

The SARS-CoV-2 3C-like proteinase (3CLpro), also known as main protease (Mpro), is a cysteine protease essential for processing viral polyproteins and thus for viral replication. It is a homodimer with a catalytic dyad composed of Cys145 and His41. Inhibition of 3CLpro prevents proper processing of viral proteins, blocking virus maturation and making it a key target for antiviral drug development against COVID-19.

Other names: MproMain ProteaseNonstructural protein 5nsp5

Mechanism of action

Inhibition of viral polyprotein processing

Biological functions

Viral polyprotein processingViral replicationProteolysis

Disease associations

InfectionCOVID-19

Safety considerations

Off-target effects due to cysteine protease activity

Beyond the preview

Go deeper on SARS-CoV-2 3C-like proteinase (3CLpro).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on SARS-CoV-2 3C-like proteinase (3CLpro).

Explore the full profile