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Target intelligence / Profile preview
SARS-CoV-2 Spike Glycoprotein (Omicron BA.5 Variant) (S protein (Omicron BA.5))
- Target
- S protein (Omicron BA.5)
- Molecular classification
- Glycoprotein, Viral Fusion Protein, Transmembrane protein
01
Overview
The SARS-CoV-2 spike (S) glycoprotein is a large, trimeric, class I fusion protein found on the surface of the virus. It mediates viral entry into host cells by binding to the human angiotensin-converting enzyme 2 (ACE2) receptor and facilitating membrane fusion. The Omicron BA.5 variant features numerous mutations in its spike protein compared to earlier strains, particularly within the receptor-binding domain (RBD), which impact both ACE2 affinity and antibody recognition.
- Other names
- Spike protein Omicron BA.5SARS-CoV-2 S glycoprotein BA.5BA.5 Spike Protein
02
Mechanism of action
Binds to ACE2 receptor to mediate viral entry; conformational changes lead to membrane fusion.
03
Biological functions
Receptor bindingMembrane fusionViral entry into host cellsImmune evasion
04
Disease associations
InfectionCOVID-19Viral pathogenesis
05
Safety considerations
Antibody resistancePotential for escape mutationsReduced vaccine efficacy
06
Interacting drugs
Neutralizing antibodies (reduced efficacy)
2 more in the full profile.
07
Biomarkers
Spike protein levels (viral load)Antibody titers against spike protein (immune response)
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