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Target intelligence / Profile preview
SARS-CoV-2 Spike Glycoprotein Receptor Binding Domain (RBD)
- Target
- RBD
- Molecular classification
- Viral protein, Glycoprotein, Receptor Ligand
01
Overview
The receptor binding domain (RBD) is a critical region within the spike (S) glycoprotein of SARS-CoV-2, responsible for binding to the ACE2 receptor on human cells and initiating viral entry. It is a major target for neutralizing antibodies and vaccines.
- Other names
- Spike RBDSARS-CoV-2 RBDReceptor Binding Domain
02
Mechanism of action
Binding to ACE2 receptor, blocking viral entry
03
Biological functions
Receptor bindingViral entryImmune evasion
04
Disease associations
InfectionCOVID-19 pathogenesis
05
Safety considerations
Potential for antibody-dependent enhancement (ADE)Evasion by viral variantsOff-target effects of inhibitors
06
Interacting drugs
Neutralizing antibodies
1 more in the full profile.
07
Biomarkers
RBD-specific antibody titers
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