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Target intelligence / Profile preview
SARS-CoV-2 Spike Glycoprotein S1 Subunit (S1)
- Target
- S1
- Molecular classification
- Glycoprotein, Viral protein, Surface antigen
01
Overview
The SARS-CoV-2 spike glycoprotein S1 subunit is a critical component of the viral spike (S) protein, mediating the virus's entry into host cells by binding to ACE2. It comprises the NTD, RBD/CTD, SD1, and SD2 domains and is heavily glycosylated. The S1 subunit is a major target for neutralizing antibodies and is used in vaccine designs and diagnostic assays. It also plays a role in immune activation, potentially contributing to cytokine release syndrome.
- Other names
- Spike S1S1 subunitSARS-CoV-2 S1Spike protein S1
02
Mechanism of action
Binds to ACE2 receptor on host cells, facilitating viral entry.
03
Biological functions
Receptor binding (ACE2)Cell entryImmune activationMediates attachment to host cells
04
Disease associations
COVID-19InfectionCytokine release syndrome
05
Safety considerations
Potential for immune evasion through mutationsContribution to cytokine storm
06
Interacting drugs
Neutralizing antibodies
2 more in the full profile.
07
Biomarkers
S1 antibody levels (for immunity)S1 antigen levels (for viral load)
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