Target intelligence / Profile preview

SARS-CoV-2 Spike Glycoprotein S2 Subunit (S2)

Target: S2
Molecular classification: Viral protein, Membrane protein, Fusion protein, Glycoprotein

Overview

The S2 subunit of the SARS-CoV-2 spike glycoprotein mediates fusion between the viral envelope and the host cell membrane, a crucial step for viral entry. It undergoes conformational changes upon proteolytic cleavage, exposing the fusion peptide and driving membrane fusion. It is a target for broadly neutralizing antibodies and next-generation vaccine design.

Other names: Spike protein S2S2 subunit

Mechanism of action

Inhibition of virus-cell membrane fusion

Biological functions

Virus-cell membrane fusionViral entryReceptor binding (indirectly through S1)Conformational change

Disease associations

InfectionCOVID-19Viral pathogenesis

Safety considerations

Potential for off-target effectsDevelopment of resistanceImmunogenicity

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