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Target intelligence / Profile preview
SARS-CoV-2 Spike Glycoprotein S2 Subunit (S2)
- Target
- S2
- Molecular classification
- Viral protein, Membrane protein, Fusion protein, Glycoprotein
01
Overview
The S2 subunit of the SARS-CoV-2 spike glycoprotein mediates fusion between the viral envelope and the host cell membrane, a crucial step for viral entry. It undergoes conformational changes upon proteolytic cleavage, exposing the fusion peptide and driving membrane fusion. It is a target for broadly neutralizing antibodies and next-generation vaccine design.
- Other names
- Spike protein S2S2 subunit
02
Mechanism of action
Inhibition of virus-cell membrane fusion
03
Biological functions
Virus-cell membrane fusionViral entryReceptor binding (indirectly through S1)Conformational change
04
Disease associations
InfectionCOVID-19Viral pathogenesis
05
Safety considerations
Potential for off-target effectsDevelopment of resistanceImmunogenicity
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