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Target intelligence / Profile preview
Spike Glycoprotein of SARS-CoV-2 (S protein)
- Target
- S protein
- Molecular classification
- Viral protein, Glycoprotein, Fusion protein
01
Overview
The SARS-CoV‑2 spike glycoprotein enables viral attachment to human cells via ACE₂ binding followed by proteolytic activation leading to membrane fusion. Its structure-function relationship underpins both pathogenesis and immune recognition—making it central both as a therapeutic/vaccine target and as an evolutionary driver during pandemic spread.
- Other names
- SARS-CoV-2 Spike proteinSpike proteinS glycoprotein
02
Mechanism of action
Inhibition of viral entry by blocking ACE2 binding or membrane fusion.
03
Biological functions
Viral entryHost cell attachmentMembrane fusionImmune evasion
04
Disease associations
COVID-19 pathogenesisInfection
05
Safety considerations
Antibody-dependent enhancement (ADE)Immune escape due to mutationsOff-target effects of vaccines
06
Interacting drugs
Neutralizing antibodies
2 more in the full profile.
07
Biomarkers
Anti-spike antibody titersRBD binding affinityNeutralization assays
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