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Target intelligence / Profile preview
SARS-CoV-2 Spike Protein Receptor Binding Domain (RBD)
- Target
- RBD
- Molecular classification
- Viral protein, Spike protein subunit, Receptor-binding domain
01
Overview
The receptor binding domain (RBD) is a critical region within the spike (S) glycoprotein of SARS-CoV-2. The RBD specifically enables the virus to recognize and bind to its primary human cellular receptor, angiotensin-converting enzyme 2 (ACE2), facilitating viral attachment and subsequent fusion with host cell membranes. It is a major target for vaccines and therapeutic interventions.
- Other names
- SARS-CoV-2 RBDSpike RBDReceptor Binding Domain
02
Mechanism of action
Blockade of viral entry by preventing RBD-ACE2 interaction
03
Biological functions
Receptor bindingViral entryACE2 interaction
04
Disease associations
InfectionCOVID-19 pathogenesis
05
Safety considerations
Potential for immune escape due to mutationsVariable efficacy against emerging variants
06
Interacting drugs
Monoclonal antibodies targeting RBD
1 more in the full profile.
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