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SARS-CoV-2 Spike Protein S2 Stem Helix (S2 Stem Helix)
- Target
- S2 Stem Helix
- Molecular classification
- Viral protein, Spike glycoprotein subunit, alpha-helical peptide
01
Overview
The S2 stem helix is a highly conserved region within the S2 subunit of the SARS-CoV-2 spike (S) glycoprotein. The stem helix lies within the S2 subunit and plays a critical role in the conformational changes required for virus-cell membrane fusion. It acts as part of the machinery stabilizing intermediate states during membrane fusion. The high degree of conservation makes it an attractive target for broadly neutralizing antibody development and pan-coronavirus vaccine design.
- Other names
- Spike S2 Stem HelixS2 helixResidues 1141-1160 of SARS-CoV-2 spike protein
02
Mechanism of action
Binding of broadly neutralizing antibodies disrupts quaternary structure formation needed for membrane fusion.
03
Biological functions
Mediates virus-cell membrane fusionStabilizes intermediate states during membrane fusionConformational change during fusion
04
Disease associations
InfectionCOVID-19Coronavirus infection
05
Safety considerations
Eliciting broadly neutralizing antibodies is rare
06
Interacting drugs
S2P6 (antibody)
1 more in the full profile.
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