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SARS-CoV-2 Spike Protein S2 Subunit (S2)

Target: S2
Molecular classification: Viral surface glycoprotein fragment

Overview

The S2 subunit of the SARS-CoV-2 spike protein mediates fusion between the viral envelope and host cell membrane, a critical step in viral entry. Its high conservation makes it a promising target for next-generation vaccines and therapeutics designed to provide broad protection across current variants as well as future zoonotic threats.

Mechanism of action

Target of broadly neutralizing antibodies

Biological functions

Mediates virus-host cell membrane fusion

Disease associations

Infection

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